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KMID : 0614720090520040417
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Journal of Korean Medical Association
2009 Volume.52 No. 4 p.417 ~ p.425
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Evidence-Based Treatment of Alzheimer’s Disease
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Lee Dong-Woo
Kim Ki-Woong
Huh Yoon-Seok
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Abstract
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The pharmacological treatment of Alzheimer’s disease is based on symptomatic therapy of cognitive decline and behavioral problems. Numerous therapies have been investigated for the treatment and prevention of Alzheimer’s disease. We reviewed the current evidence-based medical research and guidelines of treatment for Alzheimer’s disease. The use of cholinesterase inhibitors (ChEI) and N-methyl-D-aspartate (NMDA) inhibitors can bring about significant but
modest therapeutic improvement. There is insufficient evidence to recommend vitamine E, estrogen, ginko biloba, or nonsteroidal anti-inflammatory drugs (NSAIDs) for the prevention or treatment of Alzheimer’s disease. This article reviews the available data on current pharmacological treatments through evidence-based medicine.
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KEYWORD
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Alzheimer’s disease, Pharmacotherapy, Cholinesterase inhibitor, Memantine, Evidence
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